一、绪言:自1976年Meringan氏发表报告以来,干扰素(IF)治疗乙型病毒肝炎受到了人们的重视,到目前为止,取得疗效的都是大剂量IF长期给药的报告,而对临床应用的基础研究方面还很不够,用量、用法等许多问题尚待解决。最近,我们对HBs抗原阳性的肝病患者进行少量的IF(5×10u)1次给药,并在给药后不同的时间里观察HBs抗原量的变化,同时还探讨了4周总量为180×10~4u,每周分别为100× I. INTRODUCTION Since the publication of Meringan’s 1976 report, interferon (IF) treatment of hepatitis B has received considerable attention. So far, reports of long-term administration of large doses of IF have been reported, The application of basic research is still not enough, dosage, usage and many other issues to be solved. Recently, we administered a small amount of IF (5 × 10u) once to patients with HBsAg-positive liver disease and observed changes in the amount of HBs antigen at different times after administration, × 10 ~ 4u, weekly were 100 ×