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为了解慢性重症乙型肝炎患者外周血内毒素水平及其临床意义,本试验应用鲎试验改良基质显色法,定量检测了37例慢性重症乙型肝炎患者,30例慢性乙肝患者,20例健康献血者的血浆内毒素水平,其均值分别为209.3±88.5pg/ml,79.8±36.2pg/ml,<50pg/ml,慢性重症肝炎组显著高于后2组(P均<0.001),表明慢性重症乙型肝炎患者外周血内毒素水平明显高于慢性乙型肝炎患者,外周血内毒素水平的高低和乙肝患者临床病情有密切关系。从而有助于临床诊断,了解病情,制订治疗方案,掌握疗效及判断预后。
In order to understand the level of endotoxin in peripheral blood of patients with chronic severe hepatitis B and its clinical significance, this study was to assess the serum levels of 37 patients with chronic severe hepatitis B, 30 patients with chronic hepatitis B and 20 healthy The levels of plasma endotoxin in blood donors were 209.3 ± 88.5pg / ml, 79.8 ± 36.2pg / ml, <50pg / ml respectively, significantly higher in the chronic severe hepatitis group than in the latter 2 groups (all P <0.001) Serum levels of endotoxin in patients with severe hepatitis B were significantly higher than those in patients with chronic hepatitis B. The level of endotoxin in peripheral blood was closely related to the clinical condition of hepatitis B patients. To help clinical diagnosis, understanding of the disease, the development of treatment options, to master the efficacy and prognosis.