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研究观察了孕期磁共振磁场照射对子代大鼠海马突触超微结构的影响。SD孕鼠妊娠第12-18 d给予0.35T核磁共振(magnetic resonance imaging,MRI)磁场照射。测量1、2和5月龄雌性仔鼠海马CA1区和齿状回的突触结构参数,用立体计量学方法进行定量测定。结果显示,磁场照射可引起2月龄子代大鼠海马cA1区突触间隙增宽,齿状回突触活性区长度变短、突触界面曲率和活性区面密度减小;5月龄子代大鼠CA1区突触间隙增宽,突触后致密物变薄,突触界面曲率减小,齿状回突触间隙增宽。结果提示,妊娠期接受MRI磁场照射可引起海马突触超微结构的改变。对这些结构变化与行为损害之间的关系进行了讨论。
The effects of magnetic field irradiation during pregnancy on the synaptic ultrastructure in the hippocampus of offspring rats were observed. Pregnant SD rats were given 0.35T magnetic resonance imaging (MRI) magnetic field irradiation on the 12th to 18th day of gestation. The synaptic structural parameters of hippocampal CA1 region and dentate gyrus in 1, 2, and 5-month-old female offspring were measured and quantified by stereometric method. The results showed that the magnetic field irradiation could cause the widening of the synaptic cA1 in the hippocampus of 2-month-old offspring, the shortening of the dentate gyrus synaptic activation zone and the decrease of the curvature and active area density of the synaptic interface. The synaptic gap in rat CA1 area broadened, the post-synaptic density became thinner, the curvature of the synaptic interface was reduced and the width of the dentate gyrus synaptic cleft was widened. The results suggest that MRI magnetic field irradiation during pregnancy can cause changes in the ultrastructure of hippocampal synapses. The relationship between these structural changes and behavioral impairment is discussed.