目的 研究溃疡性结肠炎(UC)和克隆病(CD)患者T抑制细胞的活性及其临床意义。 方法 UC 13例,CD 10例及正常对照12例,从末梢血分离淋巴细胞,用刀豆素A诱导T抑制细胞活性,测定抑制指数。 结果 正常人抑制指数为2.44±0.46((?)±s),UC为1.52±0.65,CD为1.32±0.45,统计学差别非常显著(P<0.05)。 结论 肠道炎症性疾病患者T抑制细胞活性比正常人明显降低。 Objective To study the activity of T-suppressor cells in patients with ulcerative colitis (UC) and Crohn’s disease (CD) and its clinical significance. Methods Thirteen cases of UC, 10 cases of CD and 12 cases of normal control were divided into three groups. Lymphocytes were isolated from peripheral blood, and cytotoxicity was induced by concanavalin A. The inhibition index was determined. Results The normal control index was 2.44 ± 0.46 (± s ± s). The UC was 1.52 ± 0.65 and the CD was 1.32 ± 0.45. The difference was statistically significant (P <0.05). Conclusion T-suppressor activity in patients with inflammatory bowel disease was significantly lower than that in normal subjects.