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防治病毒性肝炎的药物按其作用特征可分为预防类、抗病毒类、抗肝损伤类和免疫调节类,兹将其中一些药物进展与应用情况简单分述如下。一、预防类药物:此类药物问世不久,有主动免疫的乙型肝炎(乙肝)疫苗和被动免疫的肝炎球蛋白,主要品种有: (一) 血源疫苗:由乙肝表面抗原(HBsAg)携带者的血液制备,国内外均已研制成功多年,北京生物制品研究所等单位已有批量生产。这种疫苗隔月注射1次,20～40μg/次,连续3次后绝大部分受者的血液中可产生较高浓度的抗乙肝表面抗原的抗体(抗-HBs)。 (二) 基因工程疫苗:是把乙肝病毒基因中能够产生HBsAg的部分移接到某种微生物或哺乳动物细胞
Prevention and treatment of viral hepatitis drugs can be classified according to their role in the role of prevention, anti-virus, anti-liver injury and immunomodulatory categories, some of these drugs will be progress and application of a brief description of the following. First, preventive drugs: the advent of such drugs soon after the active immunization of hepatitis B (hepatitis B) and passive immunization of hepatitis globulin, the main varieties are: (a) blood-borne vaccine: hepatitis B surface antigen (HBsAg) Blood preparation, both at home and abroad have been successfully developed for many years, Beijing Institute of Biological Products and other units have been mass production. The vaccine is injected once every other month from 20 to 40 μg / time. After 3 consecutive times, most of the recipients’ blood can produce higher concentrations of anti-HBs antibodies (anti-HBs). (B) genetic engineering vaccine: is the part of the hepatitis B virus gene can produce HBsAg transferred to a certain kind of microorganisms or mammalian cells