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本文对监测 DM 患者尿蛋白的4种方法和6项指标进行了临床评定。结果表明:IRIE 法24h UAIb 定量和随意尿 UAIb/UCr 指数最敏感,阳性率可达64.4%(56/87)和58.6%(51/87),依次为 UTP/UCr 指数40.2%(35/87)、CBB 法24h UTP 定量35.6%(31/87)、RIA 法 Uβ_(2m)/24h 定量32.3%(19/59),最低为试纸法尿蛋白定性检测28.7%(25/87)。UAIb/24h 定量与 UAIb/UCr 呈高度相关,阳性率无显著差异(P>0.05)。56例尿总蛋白正常(≤106.2mg/24h)的 DM 患者,用试纸法检测全为阴性,UTP/UCr 指数为5例阳性(8.9%),而UAIb/24h 定量和 UAIb/UCr 指数阳性率仍分别达48.3%(27/56)和39.3%(22/56)。结果提示 DM 肾病患者早期蛋白尿系以尿白蛋白为主,许多患者在尿总蛋白并未升高时,尿白蛋白即已升高,因而更具临床价值;IRIE 法24hUAIb 定量和随意尿 UAIb/UCr 指数是理想的监测手段和指标,后者更实用;而实检室常规试用的蛋白试纸,可靠性最低。
In this paper, four methods and six indicators of urinary protein in patients with DM were evaluated clinically. The results showed that UIEb quantitative and urinary UAIb / UCr indexes were the most sensitive in 24 h (56/87) and 58.6% (51/87) of IRAI, followed by UTP / UCr index 40.2% (35/87 ). The UB quantification was 35.6% (31/87) in CBB method and 32.3% (19/59) in Uβ_ (2m) / 24h of RIA method. The lowest detection rate was 28.7% (25/87) in urine test. UAIb / 24h quantification and UAIb / UCr were highly correlated, the positive rate was no significant difference (P> 0.05). In 56 DM patients with normal urinary protein (≤106.2mg / 24h), the negative results were all detected by the test strip method. The UTP / UCr index was positive in 5 cases (8.9%), while the positive rates of UAIb / 24h and UAIb / UCr index Still 48.3% (27/56) and 39.3% (22/56) respectively. The results suggest that early diabetic nephropathy urinary albumin-based proteinuria, urinary albumin in many patients has not increased, urinary albumin has increased, and therefore more clinical value; IRIA 24hUAIb quantitative and random urine UAIb / UCr index is the ideal means of monitoring and indicators, the latter more practical; and real test chamber routine test strips, the lowest reliability.