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13-顺维甲酸(isotretinoin)对严重的结节囊肿性痤疮有很高的疗效,它几乎能完全控制皮脂的产生,从而使皮肤和粘膜发生干燥和炎症效应,痤疮丙酸菌属的水平也明显下降,当皮肤和粘膜进一步干燥,则可消除革兰氏阴性杆菌属.以往曾有报告,在治疗革兰氏阴性菌毛囊炎和严重的结节囊肿性痤疮时,病人前鼻孔和皮肤表面金黄色葡萄球菌(金萄菌)的发生率可分别高达70%和50%.在以后的随访中,与治疗前阳性率为50%相比,当停止治疗6个月后,仍有30%的病人在前鼻孔可重新获得金萄菌,而皮肤表面除个别外,均已不能再培养到金葡菌.作者总结了18例在用13-顺维甲酸5个月疗程中或治疗结束后不发生金葡菌感染的病人,其中男性14例,女性4例,年龄15～30岁,最多见的是疖
13-isotretinoin is highly effective in the treatment of severe nodular cystic acne and has almost complete control of sebum production, resulting in dryness and inflammatory effects on the skin and mucous membranes. The level of acne bacteria Significantly decreased, when the skin and mucous membranes further dried, you can eliminate Gram-negative genus.Previously been reported in the treatment of Gram-negative folliculitis and severe cystic acne nodules, the patient’s front nostrils and skin surface The incidence of Staphylococcus aureus (Staphylococcus aureus) can be as high as 70% and 50%, respectively. In subsequent follow-up, compared with 50% before treatment, after stopping treatment for 6 months, 30% Of the patients in the former nostrils can be recoverable Staphylococcus aureus, and the skin surface with a few exceptions, are no longer cultured to Staphylococcus aureus.The author summarizes the 18 cases with 13-cis-retinoic acid during the course of 5 months or after treatment Staphylococcus aureus does not occur in patients with infection, including 14 males and 4 females, aged 15 to 30 years, the most common is 疖