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目的分析黑龙江省大规模接种双价肾综合征出血热(hemorrhagic fever with renal syndrome,HFRS)疫苗免疫效果,为以疫苗接种为主的新防控对策在省内推广和应用提供科学依据。方法在黑龙江省出血热高发病地区的重点人群中实施浙江天元生物药业股份有限公司生产的双价HFRS疫苗接种,之后分析出血热疫情变化。结果全省2008年出血热发病数与2007年同期相比下降37.78%。27个市(县)区出血热疫苗接种点2008年出血热发病数与2007年同期相比下降40.81%。2008年1-9月发病数与2007年同期相比下降24.41%。2008年10-12月出血热发病数与2007年同期相比下降60.70%,接种疫苗者无一例发病。结论疫苗接种后出血热发病率下降幅度显著增加,事实证明在出血热高发病疫区采取疫苗接种是见效最快、最安全、效果最显著的防病措施。
Objective To analyze the immune effect of Hemorrhagic Fever with Renal Syndrome (HFRS) vaccination in Heilongjiang Province and provide a scientific basis for the promotion and application of new prevention and control measures in Heilongjiang Province. Methods Double-valent HFRS vaccines produced by Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. were implemented in key populations with high incidence of hemorrhagic fever in Heilongjiang Province. The epidemic situation of haemorrhagic fever was analyzed. Results The province in 2008 the number of hemorrhagic fever decreased by 37.78% compared with the same period in 2007. 27 cities (counties) district hemorrhagic fever vaccination site in 2008 the number of onset of hemorrhagic fever compared with the same period in 2007 decreased 40.81%. The number of cases of January-September 2008 decreased by 24.41% as compared with the same period of 2007. The number of cases of hemorrhagic fever in October-December 2008 decreased by 60.70% as compared with the same period of 2007, and no case of vaccination was reported. Conclusion The incidence of hemorrhagic fever decreased significantly after vaccination. It has been proved that vaccination in the high incidence of haemorrhagic fever is the most effective, safest and most effective preventive measure.