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目的:探讨降压调脂胶囊(当归、泽泻、茯苓、白术、川芎、白芍、槟榔、陈皮、紫苏叶)对由链脲佐菌素诱发的糖尿病模型大鼠肾脏病变的保护机制。方法:采用健康雄性Wistar大鼠70只,随机分为正常组、糖尿病组、降压调脂胶囊治疗组和缬沙坦阳性对照组。连续用药4周后,收集大鼠的尿、血、肾组织标本,进行生物化学和免疫组化检测。结果:大鼠尿微量白蛋白、β2-微球蛋白、内生肌酐清除率各组间均有统计学意义;肾组织内皮素-1(ET-1)和一氧化氮合酶(NOS)表达均有统计学意义(P<0.01)。结论:降压调脂胶囊防治DN的作用与其抑制肾脏ET-1、NOS表达等因素有关。
OBJECTIVE: To investigate the protective mechanism of antihypertensive lipid capsules (Danggui, Alisma, Atractylodes, Atractylodes macrocephala, Rhizoma Chuanxiong, Paeonia lactiflorum, Areca catechu, Pericarpium tansis, Perilla frutescens) on renal lesions in diabetic rat models induced by streptozotocin. Methods: A total of 70 healthy male Wistar rats were randomly divided into normal group, diabetic group, buck-tightening lipid capsule treatment group and valsartan positive control group. Four weeks after continuous administration, the urine, blood, and kidney tissues of the rats were collected for biochemical and immunohistochemical detection. RESULTS: There were significant differences in the clearance rates of microalbumin, β2-microglobulin, and creatinine in rats between the two groups; renal tissue endothelin-1 (ET-1) and nitric oxide synthase (NOS) expression All had statistical significance (P<0.01). Conclusion: The effect of Jiangwei Tiaozhi capsule in preventing and treating DN is related to its inhibition of ET-1 and NOS expression in kidney.