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目的探讨原因不明习惯性流产的相关环境危险因素,为预防习惯性流产提供科学依据。方法采用流行病学1:2配比的病例-对照研究方法,对60例原因不明习惯性流产者和120例正常怀孕妇女相关流行病学资料进行了调查。应用SAS8.1软件对调查因素进行单因素及多因素条件Logistic回归分析。结果原因不明习惯性流产的主要危险因素是低学历(OR=10.82,95%CI:2.49～47.04)、生殖道感染(OR=3.53,95%CI:1.44～8.62)、丈夫饮酒(OR=4.75,95%CI:1.48～15.22)、现居地每日噪音暴露时间大于6h(OR=5.39,95%CI:1.03～28.22)、新家具有气味(OR=2.33,95%CI:1.07～5.06)。孕期被动吸烟、居地噪音暴露程度的增加可能与习惯性流产的发生有关联。结论低学历、生殖道感染、丈夫饮酒、现居地每日噪音暴露时间大于6h、新更换家具有气味是原因不明习惯性流产的危险因素,孕期被动吸烟可能与习惯性流产有关。
Objective To investigate the related environmental risk factors of unexplained habitual abortion and provide a scientific basis for prevention of habitual abortion. Methods The epidemiological data of 60 cases of unexplained habitual abortion and 120 cases of normal pregnant women were investigated by a 1: 2 epidemiological case-control study. SAS8.1 software was used to investigate the factors by single factor and multivariate logistic regression analysis. Results The main risk factors of unexplained habitual abortion were low education (OR = 10.82, 95% CI: 2.49-47.04), genital tract infection (OR = 3.53, 95% CI: 1.44-8.62) , 95% CI: 1.48 ~ 15.22). The daily noise exposure time was more than 6h (OR = 5.39,95% CI: 1.03 ~ 28.22) and the odor of new home (OR = 2.33, 95% CI: 1.07 ~ 5.06 ). Passive smoking during pregnancy, increased noise exposure may be associated with the occurrence of habitual abortion. Conclusion Low education, reproductive tract infection, husband drinking, daily noise exposure time is greater than 6h, the new replacement smell of furniture is an unidentified habitual abortion risk factors, passive smoking during pregnancy may be associated with habitual abortion.