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基础研究一、女性避孕免疫避孕利用妇女对人类绒毛膜促性腺激素(hCG)的主动免疫进行避孕是一种有发展前途的避孕方法。关键在于制出特种抗原,以诱发产生专一性自身抗体。但hCG的分子结构酷似LH,为避免与LH的交叉反应,从hCGβ亚基羧端的35个氨基酸制备抗原,这部分结构在LH分子中缺如。可是分子大小不够,免疫力很低,需同其它大分子抗原相结合。Stevens等(1981)将hCGβ
Basic research A female contraception immune contraception The use of women on human chorionic gonadotropin (hCG) active immunization contraception is a promising method of contraception. The key is to make a special antigen to induce the production of specific autoantibodies. However, the molecular structure of hCG resembles that of LH. To avoid the cross-reaction with LH, antigens were prepared from 35 amino acids at the carboxy terminus of hCGβ subunit. This part of the structure was absent in the LH molecule. However, the molecular size is not enough, immunity is very low, need to be combined with other macromolecular antigens. Stevens et al. (1981) identified hCGβ