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为了解血管母细胞瘤的病理形态变化特点及其间质细胞的组织来源 。对68例 血管母细胞瘤进行了组织形态学观察，并对33例进行了免疫组化染色。52例（76.6%）病程 在2月至1年之间，60例（88.2%）发生于小脑，50例（73.5%）呈囊性包块。从组织形态上可 将该瘤分为三型：经典型30例，富于细胞型21例，网状型17例。33例血管母细胞瘤的间质细 胞均对神经特异性烯醇酶（NSE）阳性，而对八因子（F-Ⅷ）、荆豆凝集素1（UEA-1）、 神 经胶质酸性蛋白（GFAP）、上皮膜抗原（EMA）均阴性。结论：血管母细胞瘤的病理形态改 变有三种基本类型；该肿瘤中的间质细胞对NSE阳性，但对F-Ⅷ、UEA-1、GFAP、EMA阴性 ，很可能具有神经内分泌分化的特点。
In order to understand the characteristics of hemangioblastoma pathological changes and the organization of the stromal cells. Histomorphological observations were performed on 68 cases of hemangioblastoma and 33 cases were immunohistochemically stained. 52 cases (76.6%) of the disease course Between February and 1 year, 60 cases (88.2%) occurred in the cerebellum, and 50 cases (73.5%) showed cystic mass. From the histomorphology, this tumor can be divided into three types: 30 in the classic type, 21 in the cell type, and 17 in the mesh type. The mesenchymal cells of 33 hemangioblastomas were positive for nerve-specific enolase (NSE), and for eight factors (F-VIII), hen bean lectin 1 (UEA-1), and glial acidic protein ( GFAP) and epithelial membrane antigen (EMA) were all negative. Conclusions: There are three basic types of pathomorphological changes in hemangioblastoma; the mesenchymal cells in this tumor are positive for NSE, but negative for F-VIII, UEA-1, GFAP, and EMA, and are likely to have the characteristics of neuroendocrine differentiation.