早在1956年首先被Adams与Purves所发现,1958年Mckenzie通过小鼠生物鉴定证实,从甲亢病人血清中分离出一种能刺激小鼠甲状腺的物质,其刺激作用比TSH缓慢而持久。曾先后命名为异常的TSH(ab-normal TSH)、异常的甲状腺刺激因子(abnormal thyroid stimulator)和甲亢的甲状腺活性因子(thyroid activatorof hyperthyroidism),后又定名为长效甲状腺刺激素(Lony Actiny ThyroidStimulator简称LATS)。 As early as 1956, Adams and Purves discovered that in 1958, Mckenzie confirmed by mouse bioassay that isolated from the serum of hyperthyroid patients a substance that can stimulate mouse thyroid gland, its stimulating effect is slower and longer than TSH. It has been named abnormal TSH (ab-normal TSH), abnormal thyroid stimulator and hyperthyroid thyroid activating factor (thyroid activator of hyperthyroidism), then named long-acting thyroid stimulating hormone (Lony Actiny ThyroidStimulator referred to LATS).