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近年来,氟对心血管系统、免疫系统功能、神经系统的功能影响成为研究重点。心肌细胞凋亡相关诱发因子导致心脏毒性的信号传递通路,可通过激活相关基因来调控心肌细胞的凋亡,引起心脏毒性。本研究通过建立氟中毒模型观察大鼠心脏毒性病变情况,并探讨氟中毒相关心脏毒性机制。1资料与方法1.1材料与方法 Wistar大鼠40只,3~4周龄,雄性,体重在70~110 g之间,购置北京华阜康动物实验
In recent years, fluoride on the cardiovascular system, immune system function, nervous system function has become the focus of research. Cardiomyocyte apoptosis-related inducers lead to cardiotoxic signaling pathways that regulate cardiomyocyte apoptosis and activate cardiotoxicity by activating related genes. In this study, the establishment of fluorosis model of cardiac toxicity in rats, and explore the mechanism of cardiotoxicity related to fluorosis. 1 Materials and Methods 1.1 Materials and Methods Wistar rats 40, 3 to 4 weeks of age, male, weighing 70 ~ 110 g, the purchase of Beijing Hua Fukang animal experiments