促性腺素释放激素增效剂(Gn R H-a)治疗子宫内膜异位症可出现因低雌激素状态所致的副作用,特别是潮热及骨质减少。因此,在应用有效的治疗手段以根除异位症病灶及症状的同时,作者将炔诺酮与高效GnRH-a联合应用以减轻上述副作用。作者对10例经腹腔镜诊断的有症状性宫内膜异位症患者进行治疗,其中6例有生育要求,平均年龄为27.4岁(21～34岁)。病人经腹腔镜术后,于黄体中期开始GnRH-a治疗。每日晨8∶00用GnRH-a自行皮下注射,持续24周。同时每日服用最小量的炔诺酮0.35mg。为减轻血管舒缩症状,炔诺酮可每日增加0.35mg,至 Gonadotropin-releasing hormone synergist (Gn R H-a) treatment of endometriosis can occur due to low estrogen-induced side effects, especially hot flashes and osteopenia. Therefore, in the application of effective treatment to eradicate ectopic lesions and symptoms, the authors also used norethindrone in combination with high-potency GnRH-a to alleviate these side effects. The authors treated 10 patients with symptomatic endometriosis diagnosed by laparoscopy, of whom 6 had fertility requirements, with an average age of 27.4 years (21-34 years). After laparoscopic surgery, patients started GnRH-a treatment in the mid luteal phase. Daily morning 8:00 with GnRH-a subcutaneous injection for 24 weeks. At the same time daily taking a minimum amount of norethisterone 0.35mg. To reduce vasomotor symptoms, norethindrone may increase 0.35mg daily