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Purpose: To study the clinical manifestations and histopathologic changes of trabeculumafter excimer laser trabeculectomy ab intemo (ELT), and to investigate the mechanismsof ELT in reducing intraocular pressure.Methods : ELT was performed on ten rabbit eyes and postoperative responses weredocumented. Comeoscleral tissue samples were harvested consecutively each week untilthe 5th postoperative week and these samples were examined under light and electricalmicroscopy.Results : Mild stimulation signs were present postoperatively in nine of ten eyes, but noserious complications were experienced. Obvious inflammation was observed in onerabbit eye as a result of iris damage during the surgical manipulations. Local fractures onthe trabecular meshwork and openings into Schlemm’ s canal were detected in all tissuesamples under light microscope. Mitochondria were found to be turgescent and dilatedlike vacuoles and endoplasmic reticula were found to be dilated under electricalmicroscope in the early p
Purpose: To study the clinical manifestations and histopathologic changes of trabeculumafter excimer laser trabeculectomy ab intemo (ELT), and to investigate the mechanisms of ELT in reducing intraocular pressure. Methods: ELT was performed on ten rabbit eyes and postoperative responses weredocumented. Comeoscleral tissue samples were harvested consecutively each week until the 5th postoperative week and these samples were examined under light and electrical microscopy. Results: Mild stimulation signs were present post postoperatively in nine of ten eyes, but noserious complications were experienced. Obvious inflammation was observed in onerabbit eye as a result of iris damage during the surgical manipulations. Local fractures on the trabecular meshwork and openings into Schlemm ’s canal were detected in all tissuesamples under light microscope. Mitochondria were found to be turgescent and dilatedlike vacuoles and endoplasmic reticula were found to be dilated under electricalmicros cope in the early p