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我们参考日本的工作,于1972年合成了氟痛新这个化合物。氟痛新(ID-1229)的化学名:3-[4-(4-氟苯基)-4-氧代丁基]1,2,3,4,5,6-六氢-6α,11α-二甲基-2,6-甲撑-8-羟基-3-苯杂唑星。本所药理组的实验结果指出,氟痛新的镇痛强度比镇痛新大,ED_(50)1.13(1.40~0.91)毫克/公斤(S.C.化学刺激法),LD_(50)54.04±5.27毫克/公斤(静脉注射)。最近国外报道,经药理试验证明,氟痛新是非麻醉性强力镇痛药,具有安定作用和肌肉
We refer to the work of Japan, in 1972, synthesized a new compound flufenamic acid. The chemical name of flurterone (ID-1229): 3- [4- (4-fluorophenyl) -4- oxobutyl] 1,2,3,4,5,6-hexahydro-6a, Dimethyl-2,6-methylene-8-hydroxy-3-benzenesulfonates. The results of our pharmacology group indicate that the new analgesic intensity of new flu pain is significantly higher than that of new analgesics, the ED 50 (1.40 ~ 0.91) mg / kg (SC chemical stimulation), the LD 50 (54.04 ± 5.27 mg) / Kg (intravenous injection). Recent foreign reports, the pharmacological test proved that the new flu is a non-narcotic analgesic pain strong, with stability and muscle