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Aim:The antihyperglycemic effects of the total ginsenosides in Chinese ginseng(TGCG),extracted from leaves and the stem,were evaluated in diabetic C57BL/6Job/ob mice.Methods:Animals received daily intraperitoneal injections of TGCG(100 and 200 mg/kg)or oral administration(150 and 300 mg/kg)for 12 d.Fastingblood glucose levels and body weight were measured after fasting the animals for4 h.Peripheral glucose use was also measured using an intraperitoneal glucosetolerance test.Results:In the injection group,a high dose of TGCG(200 mg/kg)significantly lowered the fasting blood glucose levels in ob/ob mice on d 12(153±16 mg/dL vs 203±9.8 mg/dL,P<0.01,compared to vehicle-treated group).In theoral group,blood glucose decreased notably with a dose of TGCG(300 mg/kg)ond 12(169.1±12.6 mg/dL vs 211.6±13.8 mg/dL,P<0.05,compared to the vehicle-treated group).Glucose tolerance was also improved markedly in ob/ob mice.Furthermore,a significant reduction in bodyweight(P<0.05)was observed after12 d ofTGCG(300 mg/kg)treatment in mice from the oral group.Conclusion:Theresults indicated that in a diabetic ob/ob mouse model TGCG was endowed withsignificant anti-hyperglycemic and anti-obesity properties.Therefore,the totalginsenosides extracted from Chinese ginseng leaves and the stem may have somepotential for treating diabetes.
Aim: The antihyperglycemic effects of the total ginsenosides in Chinese ginseng (TGCG), extracted from leaves and the stem, were assessed in diabetic C57BL/6 Job/ob mice. Methods: Animals received daily intraperitoneal injections of TGCG (100 and 200 mg/kg ) or oral administration(150 and 300 mg/kg) for 12 d.Fastingblood glucose levels and body weight were measured after fasting the animals for4 h.Peripheral glucose use was also measured using an intraperitoneal glucosetolerance test.Results:In the injection group, a high dose of TGCG (200 mg/kg) significantly reduced the fasting blood glucose levels in ob/ob mice on d 12 (153±16 mg/dL vs 203±9.8 mg/dL, P<0.01,committed to vehicle-treated Group). In the oral group, blood glucose decreased notably with a dose of TGCG (300 mg/kg) ond 12 (169.1±12.6 mg/dL vs 211.6±13.8 mg/dL, P<0.05, compared to the vehicle-treated group ).Glucose tolerance was also improved markedly in ob/ob mice.Furthermore,a significant reduction in bodyweight(P<0.05)was observed after12 d ofTGCG (300 mg/kg) treatment in mice from the oral group.Conclusion:Theresults indicated that in a diabetic ob/ob mouse model TGCG was endowed with significant anti-hyperglycemic and anti-obesity properties.Therefore, the totalginsenosides extracted from Chinese ginseng leaves And the stem may have somepotential for treating diabetes.