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目的探讨纳洛酮治疗首发急性右心力衰竭的临床疗效。方法将2001年1月至2007年5月首发急性右心力衰竭52例随机分为纳洛酮组(32例)和对照组(20例)。对照组按常规综合性治疗,纳洛酮组在对照组常规综合性治疗的基础上给予纳洛酮首剂0.8mg静脉注射,必要时2～4h后重复0.8mg静脉注射,继以1.2mg置于500mL液体内静脉滴注。比较治疗24h后心率、收缩压、每搏量以及心功能变化。结果纳洛酮组总有效率84.4%,病死率6.6%;对照组总有效率60%,病死率18.3%。纳洛酮组心率、收缩压、每搏量以及心功能明显改善(P<0.01),与对照组比较,疗效优于对照组(P<0.05)。结论在常规综合治疗心力衰竭的基础上,应用纳洛酮治疗首发急性右心力衰竭是有效的药物。
Objective To investigate the clinical efficacy of naloxone in the treatment of acute right heart failure. Methods Fifty-two acute right heart failure patients were randomly divided into naloxone group (n = 32) and control group (n = 20) from January 2001 to May 2007. The control group according to the conventional comprehensive treatment, naloxone group in the control group conventional comprehensive treatment based on the first dose of naloxone 0.8mg intravenously, if necessary, 2 ~ 4h after repeated 0.8mg intravenous injection, followed by 1.2mg home In 500mL liquid intravenous infusion. Heart rate, systolic pressure, stroke volume and cardiac function were compared after 24h treatment. Results The total effective rate of naloxone group was 84.4% and the case fatality rate was 6.6%. The total effective rate of control group was 60% and the case fatality rate was 18.3%. The heart rate, systolic pressure, stroke volume and cardiac function of naloxone group were significantly improved (P <0.01), and the effect was better than that of the control group (P <0.05). Conclusion Based on conventional comprehensive treatment of heart failure, the application of naloxone in the treatment of first-episode acute right heart failure is an effective drug.