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β-(5-硝基-2-呋喃)丙烯酰胺及其酯类(Ⅰ)有显著的抗日本血吸虫作用,已应用于临床。本文报道合成了N-取代-β-(5-硝基-2-呋喃)丝氨酸衍生物(Ⅱ)期望能提高抗虫效力。
β- (5-nitro-2-furan) acrylamide and its esters (Ⅰ) have a significant anti-Schistosoma japonicum effect and have been used clinically. In this paper, we report the synthesis of N-substituted-β- (5-nitro-2-furan) serine derivatives (Ⅱ) is expected to improve insect resistance.