观察大蒜素治疗难治性根尖周炎的临床疗效。方法 :经过常规根管预备和封药 (FC或CP) ,病期 1个月以上 ,根尖周窦道迁延不愈 ,叩痛长期不消 ,松动Ⅰ度以上 ,X线片显示根尖周病变累及根长 1/ 3以上的难治性根尖周炎患者 10例 ,改封大蒜素棉球 ,观察叩痛消失情况和瘘管愈合情况。结果 :大蒜素封药 1～ 3次 ,所有患者叩痛均消失 ,顺利完成根管充填。结论 :大蒜素是治疗难治性根尖周炎的有效药物之一。 To observe the clinical effect of allicin in the treatment of refractory apical periodontitis. Methods: After routine root canal preparation and sealant (FC or CP), the disease period was more than 1 month. The periapical sinus was delayed and prolonged. Ten patients with refractory periapical periodontitis involving more than one third of the root length were reformed with allicin bolls to observe the disappearance of percussion pain and fistula healing. Results: Allicin sealant 1 to 3 times, all patients were knocking pain disappear, the successful completion of root canal filling. Conclusion: Allicin is one of the effective drugs for the treatment of refractory apical periodontitis.