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目的:观察茵栀黄口服液对血型抗体高效价孕妇免疫性抗体IgG亚型的影响,评价茵栀黄口服液用于早期干预治疗母婴血型不合新生儿溶血病的药物作用机制。方法:选择2014-06-2015-12于我院检查的高效价孕妇70例,将血型免疫抗体效价ABO≥256,Rh血型抗-D效价≥64的孕妇按自愿原则随机分成常规治疗组32例和茵栀黄口服液治疗组38例。常规治疗组:VC 3g,VE 100mg 1次/d,吸氧2次/d,每次20~30min,1个月作为1个疗程;茵栀黄口服液治疗组在常规治疗的基础上服用茵栀黄口服液20ml/次,3次/d,治疗前后检测孕妇血型抗体效价及IgG亚型的变化,并对治疗的安全性及不良反应情况进行综合评价。结果:常规治疗组治疗前后各项指标变化不明显,茵栀黄口服液治疗组抗体效价及IgG亚型的含量明显降低,2组比较差异有统计学意义(P<0.05);血型抗体IgG各亚型均有不同程度降低,2组均未见明显不良反应。结论:茵栀黄口服液用于孕期干预治疗母婴血型不合新生儿溶血病具有很好的效果,对孕妇和胎儿是安全的,值得临床推广应用。
OBJECTIVE: To observe the effect of Yinzhihuang oral liquid on IgG antibody subtypes of high-titer pregnant women with blood-type antibody and to evaluate the mechanism of Yinzhihuang oral liquid for early intervention in treating neonatal hemolytic disease. Methods: Seventy patients with high titer of pregnant women who were examined in our hospital from June 2014 to June 2015 were enrolled in this study. Pregnant women with blood group antibody titer ABO ≥256 and Rh blood group anti-D titer ≥64 were randomly divided into routine treatment group 32 cases and Yinzhihuang oral solution group 38 cases. Conventional treatment group: VC 3g, VE 100mg 1 time / d, oxygen 2 times / d, each 20 ~ 30min, 1 month as a course of treatment; Yinzhihuang oral liquid treatment group on the basis of conventional treatment Zhizhuang oral solution 20ml / time, 3 times / d, before and after treatment to detect blood group antibody titer and IgG subtype changes, and the safety of treatment and adverse reactions were evaluated. Results: Before and after treatment, the indexes in the conventional treatment group did not change obviously. The antibody titer and IgG subtype in the Yinzhihuang oral liquid treatment group were significantly lower than those in the normal treatment group (P <0.05) Subtypes were reduced to varying degrees, two groups were no obvious adverse reactions. Conclusion: Yinzhihuang Oral Liquid can be used to prevent maternal and neonatal hemolytic disease during pregnancy. It has good effect on pregnant women and fetus, and is worthy of clinical application.