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近年来认为蚕蚀性角膜溃疡(Mooren溃疡)与自身免疫有关,1969年在一例本病患者中证实存在有角膜上皮的循环抗体,但未见与患者本身角膜结合的免疫球蛋白。在另一篇报告中发现结膜下上皮组织为浆细胞所包围,此进一步支持本病为抗体依赖性疾病。目前已证实了本病有与结膜上皮结合的免疫球蛋白和补体以及与结膜和角膜上皮结合的循环抗体。然而认为这些体液性自身免疫现象是蚕蚀性角膜溃疡的原因抑或结果,则尚属推测。
In recent years, Mooren ulcer (Mooren ulcer) and autoimmune related, in 1969 in a patient confirmed in this corneal epithelial circulating antibodies, but no patient’s own corneal immunoglobulin. In another report, subconjunctival epithelial tissue was found to be surrounded by plasma cells, further supporting the disease as an antibody-dependent disease. Has been confirmed that the disease has conjunctival epithelial binding of immunoglobulin and complement and with conjunctival and corneal epithelial circulating antibodies. However, it is speculated that these humoral autoimmune phenomena are the cause or result of Mooren’s ulcer.