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目的:探讨重组人干扰素α-2b栓联合膦甲酸钠氯化钠治疗人乳头状瘤病毒(HPV)感染的临床效果。方法:选取无锡市人民医院妇产科自2015年1月~2015年12月收治的120例宫颈HPV感染患者,将其随机分为治疗组和对照组,每组60例患者。对照组给予人重组干扰素α-2b栓治疗,治疗组给予人重组干扰素α-2b栓联合膦甲酸钠氯化钠静脉滴注。治疗3个月后,比较两组患者的临床疗效、HPV转阴率及肾功能损害的发生情况。结果:治疗3个月后,治疗组治愈率为63.33%,明显高于对照组的43.33%,两组相比差异有统计学意义(P<0.05);治疗组有效率为91.67%,显著高于对照组的73.33%,两组相比差异有统计学意义(P<0.05);治疗组HPV转阴率为90.00%,显著高于对照组的68.33%,两组相比差异有统计学意义(P<0.05)。治疗组治疗期间未见肾功能损害发生。结论:重组人干扰素α-2b栓联合膦甲酸钠氯化钠治疗宫颈HPV感染疗效较好,且安全性高。
Objective: To investigate the clinical effect of recombinant human interferon α-2b suppository combined with sodium foscarnet sodium chloride in the treatment of human papillomavirus (HPV) infection. Methods: A total of 120 patients with cervical HPV infection who were admitted to Wuxi People’s Hospital Obstetrics and Gynecology from January 2015 to December 2015 were randomly divided into treatment group and control group, with 60 patients in each group. The control group was treated with recombinant interferon α-2b suppository, and the treatment group was given human recombinant interferon α-2b suppository combined with foscarnet sodium and sodium chloride intravenous drip. After 3 months of treatment, the clinical efficacy, the negative rate of HPV and the incidence of renal dysfunction were compared between the two groups. Results: After 3 months of treatment, the cure rate of the treatment group was 63.33%, which was significantly higher than that of the control group (43.33%), the difference was statistically significant (P <0.05). The effective rate of the treatment group was 91.67% (73.33%) in the control group, the difference between the two groups was statistically significant (P <0.05); the treatment group HPV negative conversion rate was 90.00%, significantly higher than the control group, 68.33%, the difference between the two groups was statistically significant (P <0.05). No renal dysfunction occurred in the treatment group during the treatment. Conclusion: Recombinant human interferon α-2b suppository combined with sodium foscarnet sodium chloride in the treatment of cervical HPV infection has good curative effect and high safety.