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本文报道了脂质体包被吡喹酮治疗不同感染期的仓鼠后睾吸虫病的疗效。脂质体包被的吡喹酮由卵磷脂,胆固醇和吡喹酮按90:13.2:1的重量制成。把药物和类脂物溶解在氯仿中,使吡喹酮被包在脂质体的类脂相中。蒸发去掉氯仿后,将类脂层分散在0.15M NaCl中,放在旋涡混合器上抖动2—3分钟,使脂质体膨胀。用10倍体积的0.15M NaCl洗涤膨胀物3次,再以20,000g离心10分钟。最后把沉淀丸状物悬浮在
This article reports the efficacy of liposome-coated praziquantel in the treatment of post-testicular hymensonias at different stages of infection. Liposomally coated praziquantel is made from lecithin, cholesterol and praziquantel at a weight of 90: 13.2: 1. The drugs and lipids are dissolved in chloroform so that praziquantel is encapsulated in the lipid phase of the liposome. After evaporation of the chloroform, the lipid layer was dispersed in 0.15 M NaCl and shaken for 2-3 minutes on a vortexer to expand the liposomes. The swelling was washed three times with 10 volumes of 0.15 M NaCl and centrifuged again at 20,000 g for 10 minutes. The pellets are finally suspended in suspension