目的对比食管胃颈部单层吻合术与传统吻合术治疗食管癌的疗效。方法将2007年2月-2009年1月期间我院收治的348例食管癌患者随机分为实验组与对照组各174例,分别接受食管胃颈部单层吻合术、传统吻合术治疗。所有患者在治疗结束后再接受为期3年的随访,对比分析两组患者的疗效。结果①两组患者围手术期死亡率相比差异无统计学意义(P>0.05)。②实验组患者颈部吻合口瘘发生率、吻合口狭窄发生率显著低于对照组,且吻合口狭窄等级显著低于对照组,差异有统计学意义(P<0.05)。③两组患者术后食欲下降、胃食管反流、腹泻、体重减轻等并发症发生率相比差异无统计学意义(P>0.05);实验组患者进食困难发生率显著低于对照组,差异有统计学意义(P<0.05)。④两组患者1年生存率、3年生存率相比差异无统计学意义(P>0.05)。结论食管胃颈部单层吻合术可降低患者术后吻合口狭窄发生率以及吻合口狭窄等级,从而改善患者术后进食困难等情况。 Objective To compare the efficacy of esophagogastrostomy and traditional anastomosis in the treatment of esophageal cancer. Methods 348 cases of esophageal cancer treated in our hospital from February 2007 to January 2009 were randomly divided into experimental group and control group of 174 cases, respectively, receiving esophageal and gastric monolayer anastomosis and traditional anastomosis. All patients received a follow-up of 3 years after the end of treatment, and compared the curative effect of the two groups of patients. Results ① There was no significant difference in perioperative mortality between the two groups (P> 0.05). ② The incidence of anastomotic leakage and anastomotic stenosis in the experimental group were significantly lower than those in the control group, and the grade of anastomotic stenosis was significantly lower than that in the control group (P <0.05). ③ There was no significant difference in incidence of postoperative appetite, gastroesophageal reflux, diarrhea and weight loss between the two groups (P> 0.05). The incidence of eating difficulty in the experimental group was significantly lower than that in the control group There was statistical significance (P <0.05). ④ There was no significant difference in 1-year survival rate and 3-year survival rate between the two groups (P> 0.05). Conclusion Esophageal and gastric anastomosis can reduce the incidence of postoperative anastomotic stenosis and the level of anastomotic stenosis so as to improve the postoperative eating difficulty and so on.