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丙基硫氧嘧啶(PTU)和他巴唑(MMI)是目前内科治疗甲亢的主要药物。它们的抗甲状腺作用主要是抑制甲状腺内甲状腺激素的合成;而 PTU 还可通过干扰外周组织中甲状腺素的代谢而发挥治疗作用,但对此作用国内研究不多。心得安(PRO)是甲亢治疗中的主要辅助药物,笔者曾观察了他巴唑和心得安对甲亢的治疗作用。本研究在此基础上进一步系统比较这三种药物对甲亢患者血清甲状腺激素水平的影响,评价三者在甲亢治疗中的地位。材料与方法一、研究对象新近诊断未经治疗的甲亢114例。其中男49例,女65例;年龄18～59岁,平均36.2岁。诊断依据典型的临床表现、甲状腺吸~(131)Ⅰ率增高及血清 T_3、T_4升高。根据其临
Propylthiouracil (PTU) and methimazole (MMI) is currently the main drug for the treatment of hyperthyroidism. Their anti-thyroid effects mainly inhibit the thyroid hormone synthesis; and PTU can interfere with the metabolism of thyroid hormone in peripheral tissues to play a therapeutic effect, but the role of domestic research. Propranolol (PRO) is the main adjuvant in the treatment of hyperthyroidism, the author has observed the therapeutic effect of methimazole and propranolol on hyperthyroidism. On this basis, this study further systematically compared the impact of these three drugs on serum thyroid hormone levels in patients with hyperthyroidism, evaluation of the three in hyperthyroidism treatment status. Materials and Methods First, the object of the recent diagnosis of untreated hyperthyroidism in 114 cases. There were 49 males and 65 females, aged from 18 to 59 years, with an average of 36.2 years old. Diagnosis based on the typical clinical manifestations, thyroid suction ~ (131) Ⅰ rate and serum T_3, T_4 increased. According to its Pro