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细胞凋亡,即程序性细胞死亡,它不同于细胞坏死,是细胞接受某种信号或受到某些因素刺激后一种主动的、在一些凋亡相关基因调控下的死亡过程。某些致病因子可使细胞凋亡的调控失常。细胞凋亡的失调会引起人类许多疾病,过度的细胞凋亡可能导致器官萎缩及衰竭,细胞凋亡的不足可能导致组织器官的结构重构。本文就平滑肌细胞凋亡的调节与血管疾病的关系予以综述。
Apoptosis, which is programmed cell death, is different from cell necrosis. It is a kind of active death process under the control of some apoptosis-related genes after a cell receives some signal or is stimulated by some factors. Some of the pathogenic factors can make the regulation of apoptosis abnormal. Apoptosis disorders can cause many diseases in humans. Excess apoptosis may lead to atrophy and failure of organs. Apoptosis may lead to structural remodeling of tissues and organs. This article reviews the relationship between the regulation of vascular smooth muscle cell apoptosis and vascular smooth muscle cells.