研究背景特发性矮小(idiopathic short stature,ISS)是常见的儿科内分泌疾病之一,约占矮小症的60%80%,其发病机制复杂,受机体营养状况、内分泌激素水平、遗传因素等多方面的调节,调节生长发育的信号传导通路为生长激素-胰岛素样生长因子(GH-IGF)轴,该生长发育轴的任一环节异常均可导致ISS的发生。ISS的首选治疗药物为重组人生长激素(recombinant human
For some vehicles travelling through water,it is advantageous to cover the vehicle in a supercavity for the sake of reducing the drag acting on it. The method o