论文部分内容阅读
本文探讨了米非司酮在血液、蜕膜和绒毛中的浓度及其对流产结局的影响。服米索后６ｈ内（４～６ｈ）胎囊排出者为Ⅰ组，共３８例；服米索后６ｈ胎囊仍未排出即刻刮宫者为Ⅱ组，共２０例。应用ＨＰＬＣ分析法检测Ⅰ组、Ⅱ组早孕妇女口服米非司酮后该药物在血液、蜕膜和绒毛组织中的浓度。结果Ⅰ组用药后不同时间血液米非司酮浓度均高于Ⅱ组（Ｐ＜０．０１）；两组间绒毛组织中药物浓度无显著性差异（Ｐ＞０．０５）。蜕膜组织中，Ⅱ组药物浓度低于Ⅰ组；两组绒毛组织中米非司酮浓度均高于蜕膜组织（Ｐ＜０．０１）。实验结果提示米非司酮不但作用于蜕膜还可直接作用于绒毛组织，对流产结局产生一定影响。
This article explored the concentration of mifepristone in blood, decidua and villi and their impact on abortion outcomes. In 6 hours after taking misoprostol (4 ~ 6h), the fetus was discharged as group Ⅰ, a total of 38 cases; 6 hours after taking misoprostol did not expel immediate curettage for group Ⅱ, a total of 20 cases. The concentrations of the drug in blood, decidua and villi of the Ⅰ, Ⅱ pregnant women after oral administration of mifepristone were detected by HPLC. Results The blood concentration of mifepristone in group Ⅰ was higher than that in group Ⅱ (P <0.01). There was no significant difference in the concentration of drug among the two groups (P> 0.05). In decidua, the concentration of drug in group Ⅱ was lower than that in group Ⅰ. The concentrations of mifepristone in both groups were higher than those in decidua (P <0.01). The experimental results suggest that mifepristone can not only act on the decidua but also directly on the villous tissue, have a certain impact on the outcome of abortion.