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目的:探讨在宫颈癌患者中,应用新辅助化疗方案的临床疗效。方法:选取2010年8月-2014年8月临沧市人民医院收治的宫颈癌患者64例进行分析,将其随机分为对照组和观察组,每组32例。对照组单纯采用手术治疗方案,观察组在手术治疗前进行新辅助化疗。观察两组患者的临床治疗效果,以及并发症和术后生存情况。结果:观察组患者的治疗有效率(93.8%)明显高于对照组(75.0%),患者淋巴结转移、淋巴潴留囊肿发生率明显低于对照组,差异有统计学意义(P<0.05)。两组患者在术后1年、3年、5年生存率上相比,差异无统计学意义(P>0.05)。结论:对于宫颈癌患者而言,在手术治疗前进行新辅助化疗具有良好的效果,能够提高临床治疗有效率,减少并发症的发生,提高患者的生存质量。
Objective: To investigate the clinical efficacy of neoadjuvant chemotherapy in patients with cervical cancer. Methods: Sixty-four patients with cervical cancer admitted from August 2010 to August 2014 in Lincang People’s Hospital were selected and divided into control group and observation group randomly, 32 in each group. The control group was treated with surgical treatment only. The observation group received neoadjuvant chemotherapy before surgery. The clinical efficacy, complications and postoperative survival of the two groups were observed. Results: The treatment effective rate (93.8%) in observation group was significantly higher than that in control group (75.0%). The incidence of lymph node metastasis and lymphatic retention cyst in observation group was significantly lower than that in control group (P <0.05). There was no significant difference in the 1-year, 3-year and 5-year survival rates between the two groups (P> 0.05). Conclusion: For patients with cervical cancer, neoadjuvant chemotherapy before surgery has a good effect, which can improve the efficiency of clinical treatment, reduce the incidence of complications and improve the quality of life of patients.