家系研究表明,恶性皮肤黑色素瘤(CMM)患者的一级亲属比非亲属患CMM的风险高12倍。在具有2个以上患者或有多发性原发黑色素瘤的低年龄患者的家庭中,患者一级亲属患CMM的风险则更高。越来越多的证据表明,日光可能是恶性黑色素瘤发生的直接原因,CMM的家族易感性是由于易感家系对紫外线的敏感性增高。为了明确CMM患者一级亲属对紫外线的敏感性是否增高,我们以SCE作为检测指 Family studies have shown that first-degree relatives of patients with malignant skin melanoma (CMM) are 12 times more likely to have CMM than non-relatives. In families with more than 2 patients or low-age patients with multiple primary melanomas, the first-degree relatives of the patient are at higher risk for CMM. More and more evidence shows that sunlight may be the direct cause of malignant melanoma. The family susceptibility of CMM is due to the increased sensitivity of susceptible families to UV rays. In order to clarify whether the sensitivity of ultraviolet light in first-degree relatives of CMM patients is higher, we use SCE as the detection index.