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目的:探讨神经节苷脂(Monosia ogangioside,GM-1)治疗格尔木地区高原新生儿缺氧缺血性脑病(hypoxia ischem ia encephalop,HIE)的临床疗效。方法:收集我院2005年1月—2007年1月收治的30例新生儿缺氧缺血性脑病作为对照组,2008年1月—2010年1月30例作为治疗组,两组均采用新生儿缺氧缺血性脑病三支持、三对症的综合治疗方案,并于脑水肿急性期过后常规给予营养脑神经药物,对照组用胞二磷胆碱0.125g加入5%葡萄糖注射液10mL注射液中,疗程(7～10)天,治疗组加用神经苷脂(GM-1)20mg加入10%葡萄糖注射液20mL注射液中,每日1次静脉滴注、疗程(7～10)天。结果:治疗组显效16例,有效12例,无效2例,总有效93.3%;对照组显效10例,有效12例,无效8例,总有效率73.3%。两组总有效率比较差异有统计学意义(P<0.05)。结论:神经节苷脂能显著促进新生儿缺氧缺血性脑病的临床恢复,无明显不良反应。
Objective: To investigate the clinical efficacy of Monosialogangioside (GM-1) in the treatment of neonatal hypoxia ischemic encephalopathy (HIE) in the Golmud region. Methods: Thirty neonates with hypoxic-ischemic encephalopathy admitted in our hospital from January 2005 to January 2007 were selected as the control group. From January 2008 to January 2010, 30 cases were treated as new treatment group, Hypoxic-ischemic encephalopathy three support, three symptomatic treatment programs, and brain edema in the acute period after conventional nutrition brain nerve drugs, the control group with citicoline 0.125g 5% glucose injection 10mL injection (7 ~ 10) days, the treatment group plus 20mg GM-1 added 10% glucose injection 20mL injection, daily intravenous infusion, treatment (7 ~ 10) days. Results: In the treatment group, 16 cases were markedly effective, 12 cases were effective, 2 cases were ineffective, and the total effective rate was 93.3%. In the control group, 10 cases were markedly effective, 12 cases were effective and 8 cases were ineffective. The total effective rate was 73.3%. The total effective rate was significantly different between the two groups (P <0.05). Conclusion: Gangliosides can significantly promote the clinical recovery of neonatal hypoxic-ischemic encephalopathy without obvious adverse reactions.