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目的探讨自发性脑出血患者早期高血糖与其近期死亡率的相关性。方法检索PubMed、Embase、Cochran、万方数据库、维普咨询网、CNKI数据库等,搜索和筛选目前发表的以“早期高血糖与自发性脑出血患者近期死亡率关系”为主要研究内容的文献,提取整理相关数据。采用Meta分析评估高血糖组和非高血糖组近期死亡率RR值及95%CI,并进行发表偏倚分析。结果共纳入8篇文献,研究对象3756例。高血糖切点范围:6.1~8.3mmol/L;中位数切点:7.5mmol/L。与高血糖相关的近期死亡率RR=3.65,95%CI:3.08~4.33,P<0.01。亚组分析,A组:RR=3.46,95%CI:1.66~7.20,P=0.09;B组:RR=3.49,95%CI:2.89~4.21,P<0.01。发表偏倚均显示,Egger′s test(P>0.1),Begg′s test(P>0.05),Nfs0.05远大于纳入文献数量。结论早期高血糖增加自发性脑出血患者近期死亡风险,亚组分析尚未发现其关系受高血糖切点的影响。
Objective To investigate the correlation between early hyperglycemia and its recent mortality in patients with idiopathic cerebral hemorrhage. Methods To search and screen the published literature about the relationship between the recent mortality of patients with hyperglycemia and spontaneous intracerebral hemorrhage in PubMed, Embase, Cochran, Wanfang database, VIP consulting network and CNKI database , Extract the relevant data. Meta-analysis was used to assess the recent mortality RR and 95% CI in hyperglycemia and non-hyperglycemia groups and post publication bias analysis. Results A total of 8 articles were included and 3756 subjects were studied. Hypertension point range: 6.1 ~ 8.3mmol / L; median point: 7.5mmol / L. The recent mortality associated with hyperglycemia was RR = 3.65, 95% CI: 3.08 to 4.33, P <0.01. In the subgroup analysis, group A: RR = 3.46, 95% CI: 1.66-7.20, P = 0.09; Group B: RR = 3.49, 95% CI: 2.89-4.14, P <0.01. Publication bias showed that Egger’s test (P> 0.1), Begg’s test (P> 0.05), Nfs0.05 was much larger than the number of included articles. Conclusion Early hyperglycemia increases the risk of death in patients with spontaneous intracerebral hemorrhage. The subgroup analysis has not found that the relationship is affected by the hyperglycemic point.