论文部分内容阅读
目的:利用弥散张量成像(Diffusion tensor imaging,DTI)技术,探讨儿童青少年双相情感障碍躁狂发作(Pediatric bipolar disorder mania,PBD-mania)患者脑白质完整性的改变。方法:在湘雅二医院儿童精神科门诊收集21例年龄在10-18岁的PBD-mania患者(男/女:8/13)作为患者组,另在一学校选取18例年龄、性别与之匹配的健康受试作为对照组。所有研究对象进行磁共振扫描采集DTI数据。运用基于体素的分析法(voxel-based analysis,VBA)对DTI数据进行全脑白质的各向异性分数(Fractional anisotropy,FA)分析。结果:与正常对照组相比,PBD-mania患者右侧前扣带和左侧丘脑的FA值显著下降,未发现有FA增高的脑区。上述两区域的FA值与PBD-mania患者的疾病病程、起病年龄、发作次数以及Young躁狂量表(Young mania rating scale,YMRS)得分间均无显著的相关性。结论:前扣带与丘脑微观结构的改变可能是儿童青少年双相情感障碍发病的重要因素。
Objective: To investigate the changes of white matter integrity in children and adolescents with bipolar disorder mania (PBD-MANIA) using diffusion tensor imaging (DTI). METHODS: Twenty-one PBD-mania patients aged 10-18 years (male / female: 8/13) were enrolled in the Children’s Psychiatric Outpatient Department of the Second Xiangya Hospital as the patient group, and 18 other age-matched and sex-matched Matched healthy subjects served as control group. All subjects underwent magnetic resonance scanning to acquire DTI data. DTI data were analyzed for fractional anisotropy (FA) of whole white matter using voxel-based analysis (VBA). Results: Compared with the normal control group, the FA values of right anterior cingulate and left thalamus of PBD-mania patients were significantly decreased, and no brain area with elevated FA was found. There was no significant correlation between the FA values of the above two regions and the disease course, onset age, number of seizures and Young Mania rating scale (YMRS) in PBD-mania patients. CONCLUSIONS: The changes in the anterior cingulate and thalamic microstructures may be an important factor in the pathogenesis of bipolar disorder in children and adolescents.