本文报道了硝酸钚溶液经腹腔一次注入大鼠体内后不同时间胸腺组织超微结构损伤特点与修复规律。注后早期可见大鼠胸腺内各细胞膜系统的变化,包括核周间隙扩张,核膜溶解,线粒体与内质网肿胀。以后出现核固缩,核形不规则。在注后60天,恢复开始,180天恢复正常。 This article reports the ultrastructural characteristics and repair of thymus tissue at different times after intraperitoneal injection of lanthanum nitrate solution into rats. After injection, changes in the membrane system of the rat thymus were observed early, including expansion of the perinuclear space, dissolution of the nuclear membrane, and swelling of the mitochondria and endoplasmic reticulum. Later, nuclear condensation appeared, and the nuclear shape was irregular. 60 days after the injection, recovery began and 180 days returned to normal.