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目的查分析本院院内感染念珠菌流行情况及抗真菌药敏感性。方法利用实验室鉴定和药敏实验的方法对我院感染念珠菌情况进行分析,同时采用Sensitire Yeast Oen试验板以微量稀释法测定抗真菌药物对本院内感染所分离的念珠菌最低抑菌浓度(MIC)。结果本次共分离念珠菌260株,其中白色念珠菌检出率占61.5%,热带念菌株占18.5%,光念菌株占8.1%,近平滑念菌株占5.8%,假热带念菌株占3.8%,季也蒙念菌株占2.3%。206株念珠菌中达到氟康唑、伊曲康唑、氟胞嘧啶、制霉菌素耐药标准的分别有7.4%、13.9%、1.9%、3.3%。结论院内感染念珠菌主要由白色念菌株、热带念菌株、光念菌株及近平滑念菌株等组成,其氟康唑、伊曲康唑及氟胞嘧啶耐药率比较高。
Objective To analyze the prevalence of candidiasis in our hospital and the antifungal susceptibility. Methods The laboratory tests and susceptibility tests were used to analyze the Candida infections in our hospital. The minimum inhibitory concentrations (MICs) of antifungal agents on Candida isolated from our hospital were determined by the method of Sensitire Yeast Oen ). Results 260 strains of Candida were isolated, of which Candida albicans was detected in 61.5%, Candida tropicalis accounted for 18.5%, Candida nigra accounted for 8.1%, Candida smiths 5.8%, Candida tropicalis 3.8% , Season also missed strains accounted for 2.3%. Of the 206 strains of Candida, fluconazole, itraconazole, flucytosine and nystatin resistance were 7.4%, 13.9%, 1.9% and 3.3% respectively. Conclusion Candida nosocomial infection is mainly composed of Candida albicans, Streptococcus thermophilus, Pseudomonas aeruginosa and Pseudomonas aeruginosa, and fluconazole, itraconazole and flucytosine are more resistant.