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本文报道吡喹酮治疗慢性日本血吸虫病485例,其中晚期患者50例,伴各种加杂症者192例。治疗剂量为:总剂量60毫克/公斤1～2天疗法(413例),总剂量45毫克/公斤1天疗法(69例)和总剂量60毫克/公斤3天疗法(3例晚血)。治后1、3、6个月随访,粪孵阴转率分别为100％、99.6％和99.2％。本组病例治疗中无不良反应者125例(25.8％),中止治疗者1例(0.28％)。副反应主要是精神神经肌肉反应(头昏、头痛、乏力、肌肉颤动等)。少数出现早搏、STT波改变以及轻度消化道反应等。本组结果说明国产与进口药的疗效和副反应无明显差别。
This article reports praziquantel treatment of chronic schistosomiasis in 485 cases, of which 50 patients with advanced disease, with a variety of miscellaneous diseases in 192 cases. Therapeutic doses were: total dose of 60 mg / kg for 1 to 2 days therapy (413 cases), total dose of 45 mg / kg for 1 day therapy (69 cases) and total dose of 60 mg / kg for 3 days therapy (3 cases of late blood). Follow-up 1,3,6 months after treatment, fecal incubation negative conversion rates were 100%, 99.6% and 99.2%. This group of patients treated with no adverse reactions in 125 patients (25.8%), discontinued treatment in 1 case (0.28%). Side effects are mainly neuromuscular reactions (dizziness, headache, fatigue, muscle fibrillation, etc.). A small number of premature beats, STT wave changes and mild gastrointestinal reactions. The results of this group shows that domestic and imported drugs efficacy and side effects no significant difference.