论文部分内容阅读
目的探讨CT导向下125I粒子植入联合髂内动脉化疗灌注治疗盆腔肿瘤复发的临床疗效。方法总结8例盆腔复发肿瘤采用CT导向下125I放射性粒子植入联合髂内动脉化疗灌注患者的疗效。所有患者术前或术后给髂内动脉灌注化疗,化疗方案根据原发肿瘤的类型确定。粒子植入之前采用TPS模拟布源或遵循Halarism的125I经验公式:mCi=Da×5,Da为靶组织长、宽、高的平均值(L+W+H)/3,单位为cm,求出术中所需125I粒子的总活度及算出治疗粒子的数量。在螺旋CT导向下将125I放射性粒子植入盆腔肿瘤内。结果全组8例患者8个病灶2个月后采用PET-CT评价,完全缓解(CR)0例,部分缓解(PR)5例,稳定(NC)2例,进展(PD)1例,全组病例随访1年,死亡2例,其余6例存活,最长的生存时间15个月。结论125I放射性粒子植入联合髂内动脉灌注化疗是治疗盆腔肿瘤复发的一种有效的方法。
Objective To investigate the clinical effect of CT guided 125I seed implantation combined with internal iliac artery chemotherapy for the treatment of recurrent pelvic tumors. Methods The curative effect of CT guided 125I radioactive seed implantation combined with internal iliac artery chemotherapy in 8 patients with pelvic recurrent tumors was summarized. All patients underwent internal or external iliac artery chemotherapy before or after surgery. The chemotherapy regimen was determined according to the type of primary tumor. Before particle implantation, TPS simulated cloth source or Halarism 125I empirical formula: mCi = Da × 5, Da is the average length, width and height of the target tissue (L + W + H) / 3, in cm The total activity of the 125I particles needed during the procedure and the number of therapeutic particles were calculated. 125I radioactive particles were implanted into pelvic tumors under the guidance of spiral CT. Results Eight patients in eight groups were evaluated by PET-CT after two months. There were 0 cases of complete remission (CR), 5 cases of partial remission (PR), 2 cases of stable (NC) and 1 case of progressive (PD) Group of patients followed up for 1 year, 2 patients died, the remaining 6 survived, the longest survival time of 15 months. Conclusion 125I radioactive seed implantation combined with internal iliac artery infusion chemotherapy is an effective method for the treatment of recurrent pelvic tumors.