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研究表明冠脉内注入乙酰胆碱可引起无粥样硬化的动脉舒张而使粥样硬化的动脉收缩,向梗塞区供血的狭窄冠脉(IRSA)和向非梗塞区供血的狭窄冠脉(NIRSA)的反应,直到目前尚无定量分析。方法研究对象为32例左主干以外冠脉高度狭窄患者,分两组。A组在试验前25～725天曾发作心梗,平均59(46～74)岁的16(男14、女2)例。B组在试验前无心梗但有稳定型劳力性心绞痛,平均58(35～68)岁的16(男13、女3)例。均经心电图、~(201)铊心脏闪烁扫描仪和/或运动试验证实。在停用一般药物72小时,停用硝酸甘油等抗心绞痛药6小时后进行试验。在早晨空腹时进行冠脉造影,1分钟后在冠脉内注入乙酰胆碱,先从20μg开始,每隔5分钟逐渐增至100μg(左冠脉)或50μg(右冠脉)时,冠脉全部或
Studies have shown that intracoronary infusion of acetylcholine causes atherosclerotic atherosclerotic arteries to contract atherosclerotic arteries, narrowed coronary arteries (IRSA) that supply blood to infarcted areas, and narrow coronary arteries (NIRSA) that supply blood to non-infarcted areas Reaction, until now there is no quantitative analysis. Methods The subjects were 32 patients with severe left coronary artery stenosis, divided into two groups. A group of myocardial infarction occurred 25 to 725 days before the test, an average of 59 (46 to 74) years of age 16 (14 men and 2 women). Group B had no MI but stable angina pectoris before the test, with an average of 16 (13 males and 3 females) aged 58 to 68 years. All were confirmed by electrocardiogram, ~ (201) thallium heart scintigraphy and / or exercise test. 72 hours after stopping the general drug, disable the anti-anginal drugs such as nitroglycerin 6 hours after the test. Coronary angiography was performed on an empty stomach in the morning, and after 1 minute, acetylcholine was injected into the coronary arteries beginning at 20 μg and gradually increasing to 100 μg (left coronary artery) or 50 μg (right coronary artery) every 5 minutes