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目的:探讨以“叙事护理”为指导的全程心理护理在CIK生物免疫疗法治疗恶性肿瘤中的应用及对患者生存质量的影响。方法:选取该院收治的恶性肿瘤患者120例为研究对象，分为实验组60例和对照组60例，所有患者均给予CIK生物免疫疗法治疗，实验组在进行常规护理干预的同时给予“叙事护理”为指导的全程心理护理干预，对照组给予常规护理干预，对两组患者近期疗效、不良反应发生情况、对护理工作的满意度及治疗后1个月患者的生存质量进行对比分析。结果:所有患者均顺利完成CIK治疗，实验组总有效率高于对照组，但差异无统计学意义(n P>0.05)。在治疗期间两组患者均有个别出现发热、皮肤瘙痒及皮疹、乏力困倦、关节肌肉酸痛等1种或几种不良反应，但症状均较轻微，经对症处理后或自行缓解，未出现血常规、肝肾功能检测异常病例，两组患者不良反应发生率差异无统计学意义(n P>0.05)。实验组患者或家属对护理工作的满意度调查问卷评分和满意率明显高于对照组，护理投诉率明显低于对照组(n P0.05).The satisfaction rating and satisfaction rate of patients or family members in the experimental group were significantly higher than those of the control group, and the complaint rate of nursing was significantly lower than that of the control group (n P<0.05 orn P<0.01).The Karnofsky Performance Status(KPS) score and European Organization for Reasearch and Treatment of Cancer Quality of Life Questionnare-Core 30(EORTC QLQ-C30) scale of the two groups were significantly improved in all areas 1 month after treatment compared with that before treatment, and the improvement was more obvious in the experimental group, with statistically significant differences (n P<0.05).n Conclusions:Whole-course psychological nursing guided by “ narrative care” can enhance the confidence of patients with malignant tumors in CIK bio-immunotherapy, help patients to actively cooperate with treatment and nursing work, and play an important role in improving patients' satisfaction with nursing work and quality of life.