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子宫内膜形态和功能的发育在很大程度上受雌激素(E)、孕酮(P)的特异性受体(ER、PR)调控,上皮内PR消失时正是着床发生时。为验证上皮PR的降凋节是引起着床的关键一步,将子宫内膜PR水平与那些近来已被证明是子宫内膜接受性的可靠标记物的整合素进行对比和研究如下:分别采取156例有正常月经周期妇女其周期第20～40天的内膜标本共181份,进行形态学检查和免疫组化分析。其中80份标本取自黄体期缺陷(LPD)患者,其组织发育延迟≥3天(组1);16份取自用外源性P治疗的LPD患者(组2);21份取自轻微内膜异位症患者,组织学表现正常但整合素ανβ3水平低(组3);26份为能生育的正常对照组(组4);32份为无内异症组织发育正常的不育对照组(组5)。
The development of endometrial morphology and function is largely controlled by estrogen (E) and progesterone (P) -specific receptors (ER, PR), at the onset of implantation when intraepithelial PR disappears. To verify the hypothalamic effect of epithelial PR, a key step in implantation, the level of endometrial PR is compared with those of integrins that have recently been shown to be reliable markers of endometrial receptivity and are studied as follows: A total of 181 cases of endometrial specimens of women with normal menstrual cycles from the 20th to the 40th day were examined by morphological examination and immunohistochemistry. Eighty of the specimens were obtained from patients with luteal phase defects (LPD) with a delay in their tissue development of ≥3 days (group 1), 16 from patients with LPD treated with exogenous P (group 2), 21 In patients with mesenteric disease, histological findings were normal but low levels of integrin ανβ3 (group 3); 26 were normal controls fertile (group 4); 32 were sterile controls with normal endometriosis (Group 5).