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多囊卵巢综合征(PCOS)是育龄妇女无排卵性不孕的主要原因之一。其主要内分泌特征为高雄激素血症、高胰岛素血症和胰岛素抵抗、LH水平和LH/FSH比值升高。目前的研究发现,即使对PCOS患者进行促排卵治疗,妊娠率仍相当低。因此,不孕的因素除了慢性不排卵外,还与子宫内膜局部环境的改变有关,其不正常的内分泌状况导致的不良子宫内膜环境对胚胎发育的影响引起研究者的普遍关注。目前,子宫内膜胰岛素受体表达已成为研究的热点。
Polycystic ovary syndrome (PCOS) is one of the main causes of anovulatory infertility in women of childbearing age. The main endocrine features of hyperandrogenism, hyperinsulinemia and insulin resistance, LH levels and LH / FSH ratio increased. The current study found that, even in patients with PCOS ovulation induction treatment, the pregnancy rate is still quite low. Therefore, in addition to the factors of infertility in addition to chronic ovulation, but also with the endometrial changes in the local environment, the abnormal endocrine conditions caused by the adverse effects of endometrial environment on embryonic development caused widespread concern researchers. At present, endometrial insulin receptor expression has become a research hotspot.