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构橼酸氯菧酚(clomiphene citrate),国外商品名为Clomid,国内商品名为舒经酚。每片50mg,供口服。其化学结构和乙菧酚(己烯雌酚)近似(图1)。氯菧酚为消旋混合剂,含有两个异构体:顺式或反式。两者都具有雌激素作用与抗雌激素作用,但其强度不同。顺式-氯菧酚的抗雌激素作用较反式的强5倍,因而对增加FSH与LH的释放更有效。国外也有单纯的顺式-氯菧酚供应,每片10mg,供口服。反式-氯菧酚的雌激素作用-使阴道上皮角化的作用较顺式强10倍,因而根据用量不同可出现不同效果。氯菧酚通常发挥抗雌激素作用,导致FSH与LH分泌上升。但对发身期前儿童及
Clomiphene citrate (Clomiphene citrate), the foreign trade name Clomid, the domestic trade name Shu phenol. Each tablet 50mg for oral administration. Its chemical structure and acetophenone (diethylstilbestrol) approximation (Figure 1). Chlorophenol is a racemic mixture containing two isomers: cis or trans. Both have estrogenic and anti-estrogenic effects, but their intensity is different. Cis-chlorophenol has a 5-fold stronger antiestrogenic effect than trans, and is therefore more effective in increasing the release of FSH and LH. There is also a simple foreign cis - chlorophenol supply, each 10mg, for oral. Trans-chlorophenol estrogen effect - the role of the vaginal epithelial keratosis stronger than cis 10 times, which according to the amount of different effects can be different. Chlorophenol usually exerts anti-estrogen effects, resulting in increased FSH and LH secretion. But before the onset of children and