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目的:探讨尿β2-微球蛋白(β2-MG)检测在新生儿羊水粪染肾损害诊断中的临床意义。方法:选择我院出生的120例足月新生儿,其中羊水粪染90例按程度分成3度作为研究组,羊水清的正常新生儿30例为对照组,测定血清尿素氮(BUN)、肌酐(Cr)、尿β2-MG进行比较。结果:随着羊水粪染程度增高,BUN、Cr、尿β2-微球蛋白水平逐渐增高。其中羊水Ⅰ度、Ⅱ度、Ⅲ度粪染组BUN和Cr水平与对照组比较,差异不明显,无统计学意义(P>0.05),羊水Ⅲ度粪染组尿β2-MG水平明显高于对照组(P<0.05),Ⅰ度及Ⅱ度粪染组β2-MG与对照组比较无统计学意义(P>0.05)。结论:尿β2-MG检测对羊水粪染引起的肾功能损害早期发现及评估其程度有一定的意义。
Objective: To investigate the clinical significance of urinary β2-microglobulin (β2-MG) in the diagnosis of renal damage caused by meconium-stained amniotic fluid in neonates. Methods: A total of 120 full-term newborns born in our hospital were selected. 90 cases of meconium-stained amniotic fluid were divided into 3 degrees according to the degree and 30 normal newborns with amniotic fluid as control group. Serum urea nitrogen (BUN), creatinine (Cr), urinary β2-MG were compared. Results: The level of BUN, Cr and urinary β2-microglobulin gradually increased with the increase of meconium-stained amniotic fluid. The amniotic fluid Ⅰ, Ⅱ, Ⅲ degrees meconium staining group BUN and Cr levels compared with the control group, the difference was not statistically significant (P> 0.05), amniotic fluid Ⅲ fecal staining group urinary β2-MG levels were significantly higher Compared with the control group (P <0.05), there was no significant difference between Ⅰ and Ⅱ fecal staining group and control group (P> 0.05). CONCLUSION: The detection of urinary β2-MG for early detection of renal dysfunction caused by amniotic fluid meconium staining and the evaluation of its extent are of some significance.