一、腺苷对心脏的作用包括对冠状血管、传导系统以及心肌本身三个方面:1.冠脉扩张、流量增加。2.5μg 及50μg 腺苷使离体灌流豚鼠及家兔心脏的冠脉流量分别增加至原水平的141.8%和114.30%(二者P<0.001)。2.心率减慢及房室传导阻滞。对家兔及豚鼠的离体灌流及整体心脏都能引起窦性心动过缓,在豚鼠还可产生各种程度的房室传导阻灌。3.心收缩强度一般有所减弱,但在后期常有增强现象。二、腺苷能引起家兔明显的血压下降。三、腺苷上述作用的特点是药物用量小,效应出现快、持续时间短、复原能力强、可重复性大。 First, the role of adenosine on the heart, including coronary vessels, conduction system and the myocardium itself: 1. Coronary artery dilatation, increased flow. 2.5|Ìg and 50|Ìg adenosine increased the coronary flow volume in isolated perfused guinea pigs and rabbit hearts to 141.8% and 114.30% of the original levels, respectively (both P <0.001). 2. Slow heart rate and atrioventricular block. Isolated rabbit and guinea pig perfusion and the whole heart can cause sinus bradycardia, guinea pigs can also produce various degrees of atrioventricular conduction resistance. 3. Heart contraction intensity generally weakened, but often in the late enhancement phenomenon. Second, adenosine can cause significant drop in blood pressure in rabbits. Third, the role of adenosine The above-mentioned characteristics of the drug dosage is small, the effect appears fast, short duration, recovery ability, reproducibility.