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为了探讨ｎｍ２３蛋白在肺癌早期诊断中的价值及其与肺门或纵隔淋巴结转移的关系，采用ＳＰ法对３６例肺癌和３６例肺良性疾病患者，在术前以纤支镜取材并作ｎｍ２３蛋白免疫组织化学研究。结果显示：肺癌组纤支镜刷检涂片和活检组织标本中ｎｍ２３蛋白阳性率低于肺良性疾病组（Ｐ＜０．０５），肺癌组中有肺门或纵隔淋巴结转移的病例（Ｎ１～Ｎ３），ｎｍ２３蛋白阳性率低于无淋巴结转移的病例（Ｐ＜０．０５）。结果表明术前纤支镜取材检测ｎｍ２３蛋白，对肺癌诊断及术前判断有无肺门或纵隔淋巴结转移有一定的参考价值。
To investigate the value of nm23 protein in the early diagnosis of lung cancer and its relationship with hilar or mediastinal lymph node metastasis, SP method was used to obtain 36 nm23 lung cancer and 36 lung benign disease patients by preoperative bronchoscopy. Immunohistochemistry study. The results showed that the positive rate of nm23 protein in fibrobronchoscopic smears and biopsy specimens of the lung cancer group was lower than that in the benign lung disease group (P<0.05), and there was a case of hilar or mediastinal lymph node metastasis in the lung cancer group (N1～ N3), the positive rate of nm23 protein was lower than that without lymph node metastasis (P<0.05). The results showed that the detection of nm23 protein by preoperative bronchoscopy had certain reference value for the diagnosis of lung cancer and preoperative judgment of hilar or mediastinal lymph node metastasis.