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目的探讨人表皮生长因子受体2(HER2)基因与新疆维吾尔族(维族)、汉族胃癌患者临床病理特征的相关性及其临床意义。方法采用免疫组织化学染色及荧光原位杂交检测108例汉族和52例维族患者胃癌组织中HER2状态的表达,并预测其对胃癌预后的影响。结果 160例患者HER2基因表达总阳性率为10.00%(16/160),维族HER2基因表达阳性率为15.38%(8/52),汉族HER2基因表达阳性率为7.41%(8/108)。HER2基因表达阳性与性别、年龄、族别、肿瘤大小、肿瘤病理类型、TNM分期、浸润深度、淋巴结转移、远处转移、神经是否受侵、淋巴管内是否有癌栓、贫血及癌胚抗原无相关性(P均>0.05),而与肿瘤部位、Lauren分型及分化程度相关(P均<0.05)。结论 HER2基因检测可以作为评估新疆维汉民族胃癌恶性生物学行为及预后的指标。
Objective To investigate the relationship between HER2 gene and clinicopathological features of Uygur and Han nationality gastric cancer in Xinjiang and its clinical significance. Methods Immunohistochemical staining and fluorescence in situ hybridization were used to detect the expression of HER2 in 108 cases of Han and 52 Uygur patients and to predict the prognosis of gastric cancer. Results The positive rate of HER2 gene expression in 10 cases was 10.00% (16/160), the positive rate of HER2 gene in Uighur was 15.38% (8/52), and the positive rate of HER2 gene expression in Han Han was 7.41% (8/108). The positive expression of HER2 gene was related to sex, age, ethnicity, tumor size, tumor pathological type, TNM stage, depth of invasion, lymph node metastasis, distant metastasis, invasion of nerve, lymphatic tumor thrombus, anemia and carcinoembryonic antigen (P> 0.05), but correlated with the tumor location, Lauren classification and differentiation (all P <0.05). Conclusion The HER2 gene test can be used as an indicator to evaluate the malignant biological behavior and prognosis of gastric cancer in ethnic Chinese in Uighur.