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In order to investigate the association of G+1688A(Ser563Asn) polymorphism of platelet endothelial cell adhesion molecule-1(PECAM-1) gene with myocardial infarction(MI) in the Chinese Han population,the G+1688A polymorphism in PECAM-1 gene was detected by polymerase chain reaction-restriction fragment-length polymorphism(PCR-RFLP) method among 502 subjects,including 218 patients with MI and 284 controls.The results showed that there was significant difference in AA frequencies of genotype G+1688A polymorphism between case and control groups(39% vs 24%,P<0.001).A similar trend was observed on the allele frequencies(A/G:62% vs 49%,P<0.001).Among the subjects with high serum total cholesterol level or high systolic blood pressure level,the variant AA genotype was associated with high risk of MI(adjusted OR,2.13;95% CI,1.08-4.41 and adjusted OR,2.53;95%CI,1.63-3.63).The single nucleotide polymorphism(SNP) at position +1688 in the exon 8 of PECAM-1 gene was associated with MI and the allele A might be a risk factor for MI in the Chinese Han population.
In order to investigate the association of G + 1688A (Ser563Asn) polymorphism of platelet endothelial cell adhesion molecule-1 (PECAM-1) gene with myocardial infarction (MI) in the Chinese Han population, the G + 1688A polymorphism in PECAM- 1 gene was detected by polymerase chain reaction-restriction fragment-length polymorphism (PCR-RFLP) method among 502 subjects, including 218 patients with MI and 284 controls. The results showed that there was significant difference in AA frequencies of genotype G + 1688A polymorphism between cases and control groups (39% vs 24%, P <0.001) .A similar trend was observed on the allele frequencies (A / G: 62% vs 49%, P <0.001) .Among the subjects with high serum total cholesterol level or high systolic blood pressure level, the variant AA genotype was associated with high risk of MI. (adjusted OR, 2.13; 95% CI, 1.08-4.41 and adjusted OR, 2.53; 95% CI, 1.63-3.63) .The single nucleotide polymorphism SNP) at position +1688 in the exon 8 of PECAM-1 gene was associated with MI and the allele A might be a risk factor for MI in the Chinese Han population.