本文采用随机、双盲及前瞻性方法,将高三尖杉酯碱(Homoharringtonine,H.H)和5-氟尿嘧啶(5-Fluorouracil,5-FU)用于难治性青光眼滤过手术。比较了两者对滤过手术疗效的影响及其毒副作用。其中,H.H组24只眼,5-FU组23只眼。随诊10～20个月(平均18个月),研究结果显示:(1)H.H组功能性滤过泡累计百分率为84.9％,显著高于5-FU组(62.2％)(P<0.05);(2)H.H组的累计手术成功率为85.7％,显著高于5-FU组(61.1％)(P<0.05),(3)H.H组角膜上皮缺损的发生率为20.8％,低于5-FU组(52.2％)(P<0.05)。其他并发症两组间无差别。 Homoharringtonine (H.H) and 5-Fluorouracil (5-FU) were used in refractory glaucoma filtration surgery in a randomized, double-blind and prospective manner. The effects of the two on the curative effect of filtration surgery and their toxicities and side effects were compared. Among them, 24 eyes of H.H group and 23 eyes of 5-FU group. The results showed that: (1) The cumulative percentage of functional bleb in HH group was 84.9%, significantly higher than that in 5-FU group (62.2%) (P <0.05) ; (2) The cumulative operative success rate in HH group was 85.7%, significantly higher than that in 5-FU group (61.1%) (P <0.05); (3) The incidence of corneal epithelial defect in HH group was 20.8% -FU group (52.2%) (P <0.05). Other complications no difference between the two groups.